According to the recently published report ''; Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 184.108.40.206) pipeline Target constitutes close to 32 molecules.
Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 220.127.116.11) - Tyrosine-protein kinase JAK3 is an enzyme encoded by the JAK3 gene. It is involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. It plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins.
The report '' outlays comprehensive information on the Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 18.104.22.168) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 22.214.171.124) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 2, 4, 6, 1, 16 and 3 respectively. Report covers products from therapy areas Immunology, Dermatology, Gastrointestinal, Musculoskeletal Disorders, Oncology, Respiratory, Ophthalmology and Cardiovascular which include indications Rheumatoid Arthritis, Atopic Dermatitis (Atopic Eczema), Inflammatory Bowel Disease, Alopecia Areata, Psoriasis, Ulcerative Colitis, Vitiligo, Asthma, Crohn's Disease (Regional Enteritis), Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE), Dermatomyositis, Diffuse Large B-Cell Lymphoma, Inflammation, Systemic Lupus Erythematosus, Allergic Conjunctivitis, Anaplastic Large Cell Lymphoma (ALCL), Androgenic Alopecia, Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy, Ankylosing Spondylitis (Bekhterev's Disease), Arthritis, Autoimmune Disorders, B-Cell Chronic Lymphocytic Leukemia, B-Cell Non-Hodgkin Lymphoma, Cachexia, Celiac Disease, Chronic Obstructive Pulmonary Disease (COPD), Colorectal Cancer, Cutaneous T-Cell Lymphoma, Dermatitis (Eczema), Dermatosis, Fibrosis, Follicular Lymphoma, Ischemia Reperfusion Injury, Lung Transplant Rejection, Mantle Cell Lymphoma, Marginal Zone B-cell Lymphoma, Myeloproliferative Disorders, Pemphigus Vulgaris, Peripheral T-Cell Lymphomas (PTCL), Polyarticular Juvenile Idiopathic Arthritis (PJIA), Pruritus, Psoriatic Arthritis, Sarcoidosis, Sarcopenia, Systemic Sclerosis (Scleroderma) and Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma).
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.