The National Toxicology Program (NTP) has issued a request for information on 20 substances—six of which are commonly used in the cosmetics and dietary supplement industry—that have been nominated for possible review for future editions of the agency’s Report on Carcinogens (RoC). Specifically, NTP seeks the following: (i) data on current production, use patterns and human exposure; (ii) information about published, ongoing or planned studies related to evaluating carcinogenicity; (iii) scientific issues important for assessing carcinogenicity of the substance; and (iv) names of scientists with expertise or knowledge about the substance.

Among the substances listed are (i) aloe vera whole leaf extract, an herbal remedy also used in health care products and cosmetics; (ii) coconut diethanolamide, used in cosmetics, shampoo and soap; (iii) the dietary supplements ginkgo biloba extract, goldenseal root powder and kava extract; and (iv) pulegone, a flavoring used as a fragrance and herbal medicine. Information submissions will be accepted until October 18, 2013.

See Federal Register, September 20, 2013.