The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM ) has issued its 2012-2013 biennial progress report. Composed of representatives from 15 U.S. federal regulatory and research agencies that either generate or use toxicological and safety-testing information, ICCVAM was tasked when created in 2000 with fostering new regulatory test methods that would reduce the use of animals in toxicology testing while upholding scientific quality and protecting human and animal health, and the environment.

According to the report, many of its recommendations have not been used for regulatory decision making during its first 15 years, so ICCVAM has taken a new approach under which partner agencies will drive its activities and its scope will expand “to provide bioinformatics and computational toxicology support to the DNTP [Division of the National Toxicology Program] overall and the DNTP ’s Biomolecular Screening Branch.” ICCVAM is still developing new operating procedures and planning future activities under the approach. See NTP News, August 4, 2014.