The European Commission’s Scientific Committee for Consumer Safety (SCCS) recently published three opinions finding that 3-amino-2,6-dimethylphenol, hydroxyethoxy aminopyrazolopyridine HCl and Basic Brown 17 are safe for use in hair dyes at a maximum concentration of 2 percent. The committee provides opinions on the health and safety risks of non-food consumer products and services on the basis of dossiers submitted by industry applicants or member state authorities to satisfy EU regulatory requirements.
As part of its toxicological evaluation for each of these substances, SCCS assessed acute oral, dermal and inhalation toxicity; skin irritation and mucous membrane irritation; skin sensitization; percutaneous absorption; repeated dose toxicity; mutagenicity/genotoxicity; carcinogenicity; reproductive toxicity; toxicokinetics; and photo-induced toxicity. Concluding from these data that hydroxyethoxy aminopyrazolopyridine HCl is “a strong sensitizer,” SCCS also noted “a sensitization potential” for 3-amino-2,6-dimethylphenol and Brown Basic 17. The committee also added that, “Basic Brown 17 may contain up to 4.5 % (w/w) Basic Red 118, corresponding to maximum 0.09% in a hair dye formulation. Basic Red 118 according to the Cosmetic Regulation (Regulation 1223/2009) is not permitted for use in cosmetics except as an impurity in Basic Brown 17.”