On September 1, 2011, HHS published a notice extending the comment period for the advance notice of proposed rulemaking (ANPRM) on how current regulations for protecting human subjects might be modernized and revised to be more effective. That ANPRM, entitled "Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing Burden, Delay, and Ambiguity for Investigators," was published in the Federal Register on July 26, 2011, with a comment deadline of September 26, 2011. Since the ANPRM was published, HHS has received requests to extend the comment period to allow sufficient time for a full review of the ANPRM. In response to these requests, the comment period will be extended by 30 days to October 26, 2011.