EPA released a final human health assessment for trichloroethylene (TCE ) on September 28, 2011, classifying the chemical as “carcinogenic to humans.” The Integrated Risk Information System (IRIS ) assessment also concludes that TCE can harm the central nervous system, kidneys, liver, male reproductive system, immune system, and the developing fetus. EPA’s classification is consistent with the World Health Organization’s classification of TCE as a probable human carcinogen and the U.S. Toxicology Program’s listing of the chemical as “reasonably anticipated” to cause human cancer.

Used primarily as a solvent, TCE has been identified as a chemical of concern at 761 CERCL A sites and at 1,750 Department of Defense contaminated sites. Many of those sites have been remediated or are being remediated, but approximately 400 remain to be cleaned up.