The European Chemicals Agency (ECHA) has published a list of 4,415 substances that will be registered by November 30, 2010, under the European Union’s registration, evaluation and authorization of chemicals (REACH). The agency compiled the list from information supplied by companies concerning their plans to register substances. The November deadline is the first major deadline for substance registrations under REACH. It applies to substances manufactured in, or imported into, EU member states in annual volumes of 1,000 metric tons or more and to some toxic substances at lower volumes. According to the agency, after the November 30 deadline, “it will be illegal to manufacture or sell [nonregistered substances] within the EU.” See ECHA Press Release, April 16, 2010.