On 8 April 2015, the U.S. Treasury Department designated the Cartel de Jalisco Nueva Generacion ("CJNG"), Los Cuinis Drug Trafficking Organization ("DTO"), and their leaders Nemesio Oseguera Cervantes and Abigael Gonzalez Valencia, respectively, pursuant to the Foreign Narcotics Kingpin Designation Act ("Kingpin Act"). The Treasury Department has cited these relatively young allied organisations as emerging powers in Mexican drug trafficking.

The Department of Treasury alleges that Cervantes, a Mexican National, formed CJNG from the remnants of the Milenio Cartel, which disbanded when its leadership were captured. CJNG is based primarily in the Mexican states of Jalisco, Michoacan and Colima. It has also proven particularly adept at expansion and networking with international criminal organisations, which has led to a rapid expansion and violent confrontations with other drug trafficking organisations, according to the Treasury Department. Individually, Mr. Cervantes has been convicted of conspiracy to distribute heroin and served three years in prison in the United States.

Similar to CJNG, the DTO is also described as consisting primarily of former Milenio Cartel members and is said to focus on cocaine and methamphetamine trafficking. Its leader, Valencia, is Cervantes' brother-in-law. Valencia was detained in late February 2015. Both Valencia and Cervantes were indicted in the U.S. District Court for the District of Columbia for leading a continuing criminal enterprise, among other charges.