In the largest single delisting in Treasury's sanctions history, 308 individuals and entities tied to Cali Cartel leaders Miguel and Gilberto Rodriguez Orejuela were removed from the Specially Designated Nationals and Blocked Persons (SDN) List on June 19th. The action came after the cartel collapsed economically.

In 2004, following the Colombian government's seizure and subsequent oversight of Orejuela companies, OFAC issued a licensing policy for U.S. companies dealing with 11 different companies, including Copservir, one of Colombia's largest drug store chains. Because of the close relationship between the Governments of the United States and Colombia, OFAC issued licenses to engage in transactions with these SDNs but established restrictions on the payment streams in order to ensure funds were not diverted.